Mastitis is the most common and troubling outcome of immune suppression. As a potential gateway for bacteria, the other has several natural lines of defense. If these defense mechanisms do not completely succeed in preventing invading pathogens from entering the other, the bacteria can travel upwards into the milk ducts and the alveoli should the neutrophils of the immune system become impaired or suppressed infection will occur.
The resulting severe inflammatory reaction mastitis can lead to tissue damage and ultimately to the death of the affected animal. commercially produced bovine bG-CSF(Granulocyte colony-stimulating factor) helps restore normal neutrophil function and increases the number of neutrophils improving their ability to destroy invading bacteria. site-specific pegylation prolongs the activity of the molecule by slowing down its degradation inside the cow’s body. As a result, more optimally functioning neutrophils are available so mastitis cannot develop.